First in Japan Submitted a notification of Food with Functional Claims for liver function with a new ingredient “Garcinol from Indian mangosteen”.

Toyo Shinyaku Co.,Ltd. (Head Office: Fukuoka City, Fukuoka Prefecture; Headquarters: Tosu City, Saga Prefecture; President: Toshimitsu Hattori) has submitted a notification for a food with functional claims “Indian mangosteen-derived garcinol” as a functionally active ingredient with a label stating that it “reduces slightly elevated blood ALT and AST levels in the normal range. The notification was published on January 4, 2024.

*Blood ALT and AST levels are one of the indicators of liver health.

Toyo Shinyaku submitted a notification to the Consumer Affairs Agency for “Indian Mangosteen Tablet L” containing “Indian mangosteen-derived garcinol,” a characteristic ingredient of the Indian mangosteen, as a functionally indicated food, and it was made public as of January 4, 2024. (Notification No.: I909) Garcinol from the Indian mangosteen is a new functional ingredient that has never been reported before.

We prepared a systematic review (SR) based on human study data conducted by our company and submitted a notification with the indication of “reduces slightly elevated blood ALT and AST levels in the healthy range.

Notification details
Product Name : Indian Mangosteen Tablet L
Notification No. : I909
Amount of functionally active ingredient contained in each recommended daily intake :
［Name of functionally active ingredient] Indian mangosteen-derived garcinol
［Content] 18.0 mg/day
Submitted Claim :
This product contains garcinol from the Indian mangosteen. Garcinol derived from the Indian mangosteen has been reported to have the ability to lower blood ALT and AST levels, which are slightly elevated in healthy people in the normal range. Blood ALT and AST levels are one of the indicators of liver health.